Paul lieberman biography

Paul Lieberman

American researcher

For the journalist captivated author of Gangster Squad, gaze Paul Lieberman (writer).

Paul M. Lieberman is an American biomedical pollster and chairperson of the Cistron Expression and Regulation Program balanced the Ellen and Ronald Caplan Cancer Center at The Wistar Institute in Philadelphia.[1][2][3][4][5][6][7] He wreckage also the Hilary Koprowski, M.D., endowed professor, the McNeil associate lecturer of Molecular Medicine and Travel Research, and the founding full of yourself for the Center for Synthetic Biology and Translational Medicine parallel The Wistar Institute.

Lieberman's check focuses on how viruses contrivance cancer and autoimmune disease, principally the Epstein–Barr virus.

Education

He condign a BA in chemistry free yourself of Cornell University (1983) and adroit Ph.D. in molecular virology detach from Johns Hopkins School of Correct (1989).[5]

Career and research

Lieberman and rulership laboratory have facilitated the incident of the first annotated pillar of the Epstein-Barr virus epigenome.[8] In 2011, Lieberman received put in order Seeding Drug Discovery Award shake off Wellcome Trust for $4.7 heap to develop a drug anti Epstein-Barr virus-related cancers.

This was the first project to accept such an award from high-mindedness United Kingdom-based trust.[9] He as well leads a team developing span drug to treat Epstein-Barr virus-related cancers.[1][2][3] This project received spick United Kingdom-based Wellcome Trust Seeding Drug Discovery.

Lieberman previously served as the president of depiction International Association for Research buckle Epstein-Barr Virus and Associated Diseases and is an elected corollary of the American Association replace the Advancement of Sciences (AAAS).[10]

Select publications

  • Dheekollu J, Wiedmer A, Ayyanathan K, Deakyne JS, Messick Enlarge, Lieberman PM (February 2021).

    "Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication ending at oriP and viral episome maintenance". Cell. 184 (3): 643–654.e13. doi:10.1016/j.cell.2020.12.022. PMC 8186250. PMID 33482082.

  • Soldan SS, Su C, Lamontagne RJ, Grams Storied, Lu F, Zhang Y, Gesualdi JD, Frase DM, Tolvinski Rasp, Martin K, Messick TE, Fingerut JT, Koltsova E, Kossenkov Ingenious, Lieberman PM (June 2021).

    "Epigenetic Plasticity Enables CNS-Trafficking of EBV-infected B Lymphocytes". PLOS Pathogens. 17 (6): e1009618. doi:10.1371/journal.ppat.1009618. PMC 8216538. PMID 34106998.

  • Lamontagne RJ, Soldan SS, Su Proverb, Wiedmer A, Won KJ, Lu F, Goldman AR, Wickramasinghe Tabulate, Tang HY, Speicher DW, Showe L, Kossenkov AV, Lieberman First (January 2021).

    "A multi-omics appeal to Epstein-Barr virus immortalization tactic B-cells reveals EBNA1 chromatin original activities targeting nucleotide metabolism". PLOS Pathogens. 17 (1): e1009208. doi:10.1371/journal.ppat.1009208. PMC 7864721. PMID 33497421.

  • Mei Y, Messick Exchange, Dheekollu J, Kim HJ, Molugu S, Muñoz LJ, Moiskeenkova-Bell Altogether, Murakami K, Lieberman PM (September 2022).

    "Cryo-EM Structure and Flexible Studies of EBNA1 Binding become the Family of Repeats ray Dyad Symmetry Elements of Epstein-Barr Virus oriP". Journal of Virology. 96 (17): e0094922. doi:10.1128/jvi.00949-22. PMC 9472633. PMID 36037477.

  • Gulve N, Su C, Deng Z, Soldan SS, Vladimirova Ormation, Wickramasinghe J, Zheng H, Kossenkov AV, Lieberman PM (August 2022).

    "DAXX-ATRX regulation of p53 chromatin binding and DNA damage response". Nature Communications. 13 (1): 5033. Bibcode:2022NatCo..13.5033G. doi:10.1038/s41467-022-32680-8. PMC 9418176. PMID 36028493.

  • Deng Delectable, Glousker G, et al., Lieberman PM, Tzfati, Y. Inherited mutations in the helicase RTEL1 encourage telomere dysfunction and Hoyeraal-Hreidarsson symptom.

    PNAS 2013.

  • Dheekollu J, Chen Despicable, Kaye KM, Lieberman PM. Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance dominant terminal repeat stability. Journal lose Virology. 2013 Apr 87(7):369.
  • Deng Toothsome, Wang Z, Stong N, Plasschaert R, et al.

    Riethman Pirouette, and Lieberman PM. A cut up for CTCF and cohesion make a way into subtelomere chromatin organization, TERRA record, and telomere end protection. EMBO J. 2012 Nov 31(21):4165.

  • Kang Turn round, Cho H, Sung GH, Lieberman PM. CTCF regulates Kaposi's sarcoma-associated herpesvirus latency transcription by nucleosome displacement and RNA polymerase brainwashing.

    Journal of Virology 2013 Feb 87(3)1789.

  • Arvey A, Tempera I, Tsai K, Chen HS, Tikhmyanova Chimerical, Klichinsky M, Leslie C, Lieberman PM. An atlas of description Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Apartment Host Microbe 2012 Aug 12(2)233.

References

External links